Damien BOCHELEN
8, rue Sainte Geneviève
68100 MULHOUSE
FRANCE
e-mail: dbochelen@aol.com
Date of birth: 08-11-63
Nationality: French
Single
Professional experience
- 2000: Examinator at the European Patent Office, Munich
- 1996-99: Postdoctoral position in the Preclinical Research of Novartis Pharma AG (former Sandoz, Basel, Switzerland). Laboratory of Dr. Sauter, Neurodegeneration Unit.
- 1993-95: Postdoctoral position in the laboratory of Dr. Mersel, Laboratoire de Neurobiologie Moleculaires des Interactions Cellulaires, UPR 416 CNRS, Centre de Neurochimie, Strasbourg.
Education
- 1989-93: PhD in Cellular Neurobiology and Neurochemistry, Université Louis Pasteur, Strasbourg. Doctoral work achieved in the laboratory of Dr. Mersel, Laboratoire de Neurobiologie Moléculaires des Interactions Cellulaires, Centre de Neurochimie, Strasbourg. Dissertation: Effect of oxysterols on reactive astrocytes: inhibition of a lesion-induced reactive gliosis in rat brain and mechanism of action.
- 1988-89: DEA in Molecular and Cellular Neurobiology. Practical part achieved in the laboratory of Dr. Sensenbrenner, Laboratoire de Neurobiologie Ontogénique, UPR 417 CNRS, Centre de Neurochimie, Strasbourg. Dissertation: Factors influencing prolifération and maturation of oligodendroglial progenitor cells in culture.
- 1985-86,88: Maitrise de Biochimie,ULP, Strasbourg. Courses of Blochemistry, Molecular Genetics, Pharmacology, Organic Chemistry and Immunology.
Please click on the following link to know more about my
Languages
French (mother language), English (written) and German (fluent)
Leisure-activities
Hicking, photography, literature.
PUBLICATIONS
Articles:
Bochelen D., Eclancher F., Kupferberg A., Privat A. and Mersel M. 7ß-hydroxycholesterol and 7ß-hydroxycholesteryl-3-esters reduce the extent of reactive gliosis caused by an electrolytic lesion in rat brain. Neuroscience (1992) 51, 827-834.
Bochelen D., Lutz P., Mersel M. and Kupferberg A. Effect of oxysterol treatment on cholesterol biosynthesis and reactive astrocyte proliferation in injured rat brain cortex. J. Neurochem. (1995) 65, 2194-2200.
Bochelen D., Rudin M. and Sauter A. The Calcineurin inhibitor FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury. J. Pharmacol. Exp. Therap. (1999) 288, 653-659.
Bochelen D., Rudin M., Bjelke B. and Sauter A. Motor function deficit and recovery after transient Middle Cerebral Artery occlusion in rats: correlation with infarct size and location. Submitted to J. Cereb. Blood Flow Metab.
Reese T., Bochelen D., Sauter A., Beckmann N. and Rudin A. Magnetic resonance angiography of the rat cerebrovascular system without using contrast agent. NMR Biomed.(1999) 12, 189-196.
Werthle M., Bochelen D., Lutz P., Poulet P., Chambron J., Privat A. and Mersel M. Local administration of 7ß-hydroxycholesteryl-3-oleate prevents growth of expenmental rat C6 glioblatomas. Cancer Res. (1994) 54, 998-1003.
Gimenez y Ribotta M., Rajaofetra N., Morin-Richaud C., Alonso G, Bochelen D., Sandillon E., Legrand A., Mersel M. and Privat A. Oxysterol (7ß-hydroxycholesterol-3-Oleate) promotes serotonergic reinnervation in the lesioned rat spinal cord by reducing glial reaction. J. Neurosci. Res. (1995) 41, 79-95.
Gourmala N., Limonta S., Sauter A., Bochelen D. and Boddeke W. Localization of macrophage inflammatory protein: MIP-la and MI P-1ß expression in rat brain after peripheral administration of LPS and focal cerebral ischemia. Neuroscience (1999) 88, 1255-1266.
Rudin M., Beckmann N., Porszasz R., Reese T., Bochelen D. and Sauter A. In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives. NMR Biomed. (1999) 12, 69-97.
Oral communications
Lecture at the DEA national de chirurgie, option neurosciences chirurgicales. Réaction gliale aux lésions neuronales. 31.03-02.04 1994, Montpellier.
Bochelen D., Kupferberg A., Gimenez y Ribotta M. and Mersel M. Oxysterols are cytotoxic toward db-cAMP differentiated astrocytes. Congrès International de l'Institut de Recherche sur la Moelle Epiniere, Deauville 27-29.04.95, France.
Abstracts
Bochelen D., Eclancher F., Urban P.F. et Mersel M. Effet du 7ß-hydroxycholesterol et de ses esters sur des glioses réactionnelles induites dans le cerveau du rat. Congres du GERLI, 1991 Les Ulis, France
Bochelen D., Eclancher F., Kupferberg A. and Mersel M. 7ß-hydroxycholesterol and 7ß-hydroxycholesteryl-3-esters reduce the extent of reactive gliosis caused by an electrolytic lesion in neonatal rat brain. 9th Biennal Meeting of the International Society for Developmental Neuroscience 14-18.06.1992, La Grande Motte, France.
Bochelen D., Mersel M. and Kupferberg A. Cholesterol blosynthesis is down regulated after rat brain injury. 9th Biennal Meeting of the International Society for Developmental Neuroscience, 14-18.06.1992, La Grande Motte, France.
Bochelen D., Rudin M, Reese T. and Sauter A. A model of stroke: reversible occlusion of the middle cerebral artery in rats. Autumn Course of the Society for Cerebral Blood Flow and Metabolism, 25-28.10.96, Caen, France.
Bochelen D., Rudin M. and Sauter A. The calcineurin inhibitor FK506 alleviates the outcome of focal cerebral ischemia. 27th meeting of the Society for Neuroscience, New Orleans, October 1997.
Allegrini P., Bochelen D., Eis M., Sauter A. and Rudin M. Quantitative measurement of regional cerebral blood flow: Correlation of MRI perfusion measurements using arterial spin tagging or bolus tracking with the 14C-iodoantipyrine method. 6th meeting of the International Society for Magnetic Resonance in Medecine, April 1998, Sydney.
Bochelen D., Rudin M., Bjelke B. and Sauter A. Sensorimotor function deficits and recovery following transient middle cerebral artery occlusion in rats. XIXth International Symposium on Cerebral Blood Flow, Metabolism and Function, Copenhag, June 13-17 1999.
Bochelen D., Rudin M., Vigouret J.M. and Sauter A. Sensorimotor deficits assessed by skilled paw-reaching performance after transient middle cerebral artery occlusion in rats, improved recovery by NDD094 treatment. XIXth International Symposium on Cerebral Blood Flow, Metabolism and Function, Copenhag, June 13-17 1999.